Mobile gene cassettes and integrons in evolution

Ruth M. Hall*, Christina M. Collis, Mi Jurng Kim, Sally R. Partridge, Gavin D. Recchia, H. W. Stokes

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    135 Citations (Scopus)

    Abstract

    Integrons and the site-specific recombination systems encoded by them provide a simple mechanism for the addition of new genes to bacterial chromosomes. Although there is substantial divergence among the four known integron-encoded integrases, they all recognize the recombination sites, known as 59-base elements, that are associated with genes that are packaged in gene cassettes. In contrast, the integron associated recombination sites, att1 sites, are preferentially recognized by the cognate integrase.

    Original languageEnglish
    Pages (from-to)68-80
    Number of pages13
    JournalAnnals of the New York Academy of Sciences
    Volume870
    DOIs
    Publication statusPublished - May 1999

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