Mobile gene cassettes and integrons in evolution

Ruth M. Hall*, Christina M. Collis, Mi Jurng Kim, Sally R. Partridge, Gavin D. Recchia, H. W. Stokes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)


Integrons and the site-specific recombination systems encoded by them provide a simple mechanism for the addition of new genes to bacterial chromosomes. Although there is substantial divergence among the four known integron-encoded integrases, they all recognize the recombination sites, known as 59-base elements, that are associated with genes that are packaged in gene cassettes. In contrast, the integron associated recombination sites, att1 sites, are preferentially recognized by the cognate integrase.

Original languageEnglish
Pages (from-to)68-80
Number of pages13
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - May 1999


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