Mobile technology offers novel insights into the control and treatment of allergic rhinitis: the MASK study

Annabelle Bédard, Xavier Basagaña, Josep M. Anto, Judith Garcia-Aymerich, Philippe Devillier, Sylvie Arnavielhe, Anna Bedbrook, Gabrielle L. Onorato, Wienczyslawa Czarlewski, Ruth Murray, Rute Almeida, Joao Fonseca, Elisio Costa, Joao Malva, Mario Morais-Almeida, Ana Margarida Pereira, Ana Todo-Bom, Enrica Menditto, Cristiana Stellato, Maria Teresa VenturaAlvaro A. Cruz, Rafael Stelmach, Jane da Silva, Désirée Larenas-Linnemann, Jose M. Fuentes-Pérez, Yunuen R. Huerta-Villalobos, Regina Emuzyte, Violeta Kvedariene, Arunas Valiulis, Piotr Kuna, Boleslaw Samolinski, Ludger Klimek, Ralph Mösges, Oliver Pfaar, Sara Shamai, Isabelle Annesi-Maesano, Isabelle Bosse, Pascal Demoly, Jean-Francois Fontaine, Vicky Cardona, Joaquim Mullol, Antonio Valero, Regina E. Roller-Wirnsberger, Peter Valentin Tomazic, Niels H. Chavannes, Wytske J. Fokkens, Sietze Reitsma, Mike Bewick, Dermot Ryan, Aziz Sheikh, Tari Haahtela, Sanna Toppila-Salmi, Erkka Valovirta, Michael Makris, Nikos G. Papadopoulos, Emmanuel P. Prokopakis, Fotis Psarros, Cemal Cingi, Bilun Gemicioğlu, Arzu Yorgancioglu, Sinthia Bosnic-Anticevich, Robyn E. O'Hehir, Claus Bachert, Peter W. Hellings, Benoit Pugin, Carsten Bindslev-Jensen, Esben Eller, Ingrid Kull, Erik Melén, Magnus Wickman, Gert De Vries, Michiel van Eerd, Ioana Agache, Ignacio J. Ansotegui, Mark S. Dykewicz, Thomas Casale, Dana Wallace, Susan Waserman, Daniel Laune, Jean Bousquet, MASK study group

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)


Background: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. Objectives: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. Methods: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H 1-antihistamines were studied. Results: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid–treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H 1-antihistamines were found. Conclusions: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.

Original languageEnglish
Pages (from-to)135-143.e6
Number of pages15
JournalJournal of Allergy and Clinical Immunology
Issue number1
Publication statusPublished - Jul 2019
Externally publishedYes


  • Allergic rhinitis
  • antihistamines
  • asthma
  • conjunctivitis
  • corticosteroids
  • MASK
  • mobile health
  • treatment


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