TY - JOUR
T1 - Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden (MELD-AFP-TBS) score to stratify prognosis after liver resection for hepatocellular carcinoma
AU - Kawashima, Jun
AU - Akabane, Miho
AU - Khalil, Mujtaba
AU - Woldesenbet, Selamawit
AU - Endo, Yutaka
AU - Sahara, Kota
AU - Ruzzenente, Andrea
AU - Ratti, Francesca
AU - Marques, Hugo P.
AU - Oliveira, Sara
AU - Balaia, Jorge
AU - Cauchy, François
AU - Lam, Vincent
AU - Poultsides, George A.
AU - Kitago, Minoru
AU - Popescu, Irinel
AU - Martel, Guillaume
AU - Gleisner, Ana
AU - Hugh, Tom
AU - Weiss, Matthew
AU - Aucejo, Federico
AU - Aldrighetti, Luca
AU - Endo, Itaru
AU - Pawlik, Timothy M.
PY - 2025/7
Y1 - 2025/7
N2 - Introduction: Morphologic criteria, such as the Barcelona Clinic Liver Cancer staging system often fail to accurately predict long-term survival among patients undergoing liver resection for hepatocellular carcinoma. We sought to develop a continuous risk score that incorporates established markers of tumor biology and liver function to improve the prediction of overall survival. Methods: Data from a multi-institutional database were used to identify patients who underwent curative-intent hepatectomy for hepatocellular carcinoma. A predictive score for overall survival was developed using weighted beta-coefficients from a multivariable Cox regression model. Results: Among 850 patients, 595 (70.0%) were assigned to the training cohort, and 255 (30.0%) to the test cohort. In the training cohort, multivariable analysis identified the Model of End-Stage Liver Disease (hazard ratio, 1.04; 95% confidence interval, 1.01–1.07), log-transformed alpha-fetoprotein (hazard ratio, 1.07; 95% confidence interval, 1.02–1.13), and tumor burden score (hazard ratio, 1.07; 95% confidence interval, 1.03–1.11) as independent predictors of worse overall survival. The Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden score, based on the Cox model, stratified patients into low-risk (n = 466, 78.3%) with a 5-year OS of 70.5% and high-risk (n = 129, 21.7%) with a 5-year OS of 47.0% (P < .001). In the test cohort, the Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden score demonstrated superior discriminative accuracy (C-index: 0.72, time-dependent area under the curve 1-year: 0.80, 3-year 0.76, 5-year 0.70) compared with the Barcelona Clinic Liver Cancer staging system (C-index: 0.53, time-dependent area under the curve 1-year: 0.61, 3-year 0.55, 5-year 0.56). An online tool was made accessible at https://jk-osu.shinyapps.io/MELD_AFP_TBS/. Conclusion: The Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden score provides a novel, accurate tool for prognostic stratification of patients with hepatocellular carcinoma, identifying high-risk patients who may benefit from alternative treatments to improve outcomes.
AB - Introduction: Morphologic criteria, such as the Barcelona Clinic Liver Cancer staging system often fail to accurately predict long-term survival among patients undergoing liver resection for hepatocellular carcinoma. We sought to develop a continuous risk score that incorporates established markers of tumor biology and liver function to improve the prediction of overall survival. Methods: Data from a multi-institutional database were used to identify patients who underwent curative-intent hepatectomy for hepatocellular carcinoma. A predictive score for overall survival was developed using weighted beta-coefficients from a multivariable Cox regression model. Results: Among 850 patients, 595 (70.0%) were assigned to the training cohort, and 255 (30.0%) to the test cohort. In the training cohort, multivariable analysis identified the Model of End-Stage Liver Disease (hazard ratio, 1.04; 95% confidence interval, 1.01–1.07), log-transformed alpha-fetoprotein (hazard ratio, 1.07; 95% confidence interval, 1.02–1.13), and tumor burden score (hazard ratio, 1.07; 95% confidence interval, 1.03–1.11) as independent predictors of worse overall survival. The Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden score, based on the Cox model, stratified patients into low-risk (n = 466, 78.3%) with a 5-year OS of 70.5% and high-risk (n = 129, 21.7%) with a 5-year OS of 47.0% (P < .001). In the test cohort, the Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden score demonstrated superior discriminative accuracy (C-index: 0.72, time-dependent area under the curve 1-year: 0.80, 3-year 0.76, 5-year 0.70) compared with the Barcelona Clinic Liver Cancer staging system (C-index: 0.53, time-dependent area under the curve 1-year: 0.61, 3-year 0.55, 5-year 0.56). An online tool was made accessible at https://jk-osu.shinyapps.io/MELD_AFP_TBS/. Conclusion: The Model of End-Stage Liver Disease–alpha-fetoprotein–tumor burden score provides a novel, accurate tool for prognostic stratification of patients with hepatocellular carcinoma, identifying high-risk patients who may benefit from alternative treatments to improve outcomes.
UR - http://www.scopus.com/inward/record.url?scp=105003841430&partnerID=8YFLogxK
U2 - 10.1016/j.surg.2025.109388
DO - 10.1016/j.surg.2025.109388
M3 - Article
C2 - 40311416
AN - SCOPUS:105003841430
SN - 0039-6060
VL - 183
SP - 1
EP - 9
JO - Surgery (United States)
JF - Surgery (United States)
M1 - 109388
ER -