Modeling approach for an aortic dissection with endovascular stenting

Yasuyuki Shiraishi, Tomoyuki Yambe, Andrew J. Narracott, Akihiro Yamada, Ryosuke Morita, Yi Qian, Kazuhiko Hanzawa

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

    Abstract

    Repair of dissected aorta requires remodeling the structure of the media. Modeling approaches specific to endovascular stenting for aortic dissection have been reported. We created a goat model of descending thoracic aortic dissection and reproduced its morphological characteristics in a mock circulatory system. The purpose of this study was to examine a newly developed aortic stent which was capable of installing to the aortic dissected lesion for biomedical hemodynamics point of view. In this study, we examined the changes in hemodynamics of dissected lesions and the amelioration by endovascular stent intervention. Firstly, we performed animal experiments with the dissected aorta and examined the effects of stenting on volumetric changes in the false lumen. Secondly, we made several types of 3-D stereolithographic dissected aortic models with silicone rubber membrane between the false and the true lumens. Then, the hemodynamic characteristics in each model were evaluated in the pulsatile flow conditions in a mock circulatory system. These modelling approaches enabled the quantitative examination of post-therapeutic effects of stenting followed by elucidating of hemodynamic changes in the vicinity of stents, which may follow the management of clinical amelioration of interventional treatment with aortic stenting.
    Original languageEnglish
    Title of host publication42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
    Subtitle of host publicationEnabling Innovative Technologies for Global Healthcare, EMBC 2020
    Place of PublicationCanada
    PublisherInstitute of Electrical and Electronics Engineers (IEEE)
    Pages5008-5011
    Number of pages4
    ISBN (Electronic)9781728119908
    ISBN (Print)9781728119915
    DOIs
    Publication statusPublished - Jul 2020
    Event42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada
    Duration: 20 Jul 202024 Jul 2020

    Publication series

    NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    Volume2020-July
    ISSN (Print)1557-170X

    Conference

    Conference42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
    Country/TerritoryCanada
    CityMontreal
    Period20/07/2024/07/20

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