Modeling nicotine addiction in rats

Stephanie Caille*, Kelly Clemens, Luis Stinus, Martine Cador

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    30 Citations (Scopus)


    Among the human population, 15% of drug users develop a pathological drug addiction. This figure increases substantially with nicotine, whereby more than 30% of those who try smoking develop a nicotine addiction. Drug addiction is characterized by compulsive drug-seeking and drug-taking behaviors (craving), and loss of control over intake despite impairment in health, social, and occupational functions. This behavior can be accurately modeled in the rat using an intravenous self-administration (IVSA) paradigm. Initial attempts at establishing nicotine self-administration had been problematic, yet in recent times increasingly reliable models of nicotine self-administration have been developed. The present article reviews different characteristics of the nicotine IVSA model that has been developed to examine nicotine reinforcing and motivational properties in rats.

    Original languageEnglish
    Title of host publicationPsychiatric Disorders: Methods and Protocols
    Number of pages14
    Publication statusPublished - 2012

    Publication series

    NameMethods in Molecular Biology
    ISSN (Print)10643745


    • Intravenous self-administration
    • Lever
    • Nicotine
    • Nose poke
    • Rat model of addiction


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