Modified polypeptides and uses thereof

Roger Chung; Albert Lee; Stephanie Rayner; Marco Morsch; Luan Luu

Modified polypeptides and uses thereof

Roger Chung (Inventor), Albert Lee (Inventor), Stephanie Rayner (Inventor), Marco Morsch (Inventor), Luan Luu (Inventor)

Research output: Patent

Abstract

Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

Original language	English
Patent number	US2024199713
IPC	C07K 14/ 47 A I
Priority date	22/04/21
Publication status	Published - 20 Jun 2024

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4 Patent

Modified polypeptides and uses thereof
Chung, R., Lee, A., Rayner, S., Morsch, M. & Luu, L., 28 Feb 2024, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. EP4326340, Priority date 22 Apr 2021, Priority No. AU2021901193
Research output: Patent

Open Access
Modified polypeptides and uses thereof
Chung, R., Lee, A., Rayner, S., Morsch, M. & Luu, L., 9 Nov 2023, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. AU2022261654, 22 Apr 2022, Priority date 22 Apr 2021, Priority No. AU2021901193
Research output: Patent

Open Access
Modified polypeptides and uses thereof
Chung, R., Lee, A., Rayner, S., Morsch, M. & Luu, L., 27 Oct 2022, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. WO2022221922, 22 Apr 2022, Priority date 22 Apr 2021, Priority No. AU20210901193
Research output: Patent

Open Access

Cite this

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title = "Modified polypeptides and uses thereof",

abstract = "Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.",

author = "Roger Chung and Albert Lee and Stephanie Rayner and Marco Morsch and Luan Luu",

year = "2024",

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T1 - Modified polypeptides and uses thereof

AU - Chung, Roger

AU - Lee, Albert

AU - Rayner, Stephanie

AU - Morsch, Marco

AU - Luu, Luan

PY - 2024/6/20

Y1 - 2024/6/20

N2 - Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

AB - Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

M3 - Patent

M1 - US2024199713

ER -

Modified polypeptides and uses thereof

Abstract

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