Modified polypeptides and uses thereof

Roger Chung; Albert Lee; Stephanie Rayner; Marco Morsch; Luann Luu

Modified polypeptides and uses thereof

Roger Chung (Inventor), Albert Lee (Inventor), Stephanie Rayner (Inventor), Marco Morsch (Inventor), Luann Luu (Inventor)

Research output: Patent

Abstract

Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

Original language	English
Patent number	AU2022261654
IPC	A61P 25/ 28 A I,A61K 48/00
Priority date	22/04/21
Filing date	22/04/22
Publication status	Published - 9 Nov 2023

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Modified polypeptides and uses thereof
Chung, R. (Inventor), Lee, A. (Inventor), Rayner, S. (Inventor), Morsch, M. (Inventor) & Luu, L. (Inventor), 20 Jun 2024, IPC No. C07K 14/ 47 A I, Patent No. US2024199713, Priority date 22 Apr 2021, Priority No. AU2021901193
Research output: Patent

Open Access
Modified polypeptides and uses thereof
Chung, R. (Inventor), Lee, A. (Inventor), Rayner, S. (Inventor), Morsch, M. (Inventor) & Luu, L. (Inventor), 28 Feb 2024, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. EP4326340, Priority date 22 Apr 2021, Priority No. AU2021901193
Research output: Patent

Open Access
Modified polypeptides and uses thereof
Chung, R. (Inventor), Lee, A. (Inventor), Rayner, S. (Inventor), Morsch, M. (Inventor) & Luu, L. (Inventor), 27 Oct 2022, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. CA3215808, Priority date 22 Apr 2021, Priority No. AU2021901193
Research output: Patent

Open Access

Cite this

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title = "Modified polypeptides and uses thereof",

abstract = "Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.",

author = "Roger Chung and Albert Lee and Stephanie Rayner and Marco Morsch and Luann Luu",

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language = "English",

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AU - Chung, Roger

AU - Lee, Albert

AU - Rayner, Stephanie

AU - Morsch, Marco

AU - Luu, Luann

PY - 2023/11/9

Y1 - 2023/11/9

N2 - Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

AB - Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

M3 - Patent

M1 - AU2022261654

Y2 - 2022/04/22

ER -

Modified polypeptides and uses thereof

Abstract

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