Modifiers of epigenetic reprogramming show paternal effects in the mouse

Suyinn Chong, Nicola Vickaryous, Alyson Ashe, Natasha Zamudio, Neil Youngson, Sarah Hemley, Tomas Stopka, Arthur Skoultchi, Jacqui Matthews, Hamish S. Scott, David de Kretser, Moira O'Bryan, Marnie Blewitt, Emma Whitelaw

Research output: Contribution to journalArticleResearchpeer-review

Abstract

There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.

LanguageEnglish
Pages614-622
Number of pages9
JournalNature Genetics
Volume39
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

Keywords

  • POSITION EFFECT VARIEGATION
  • SMALL RNAS
  • EMBRYONIC-DEVELOPMENT
  • METHYLATION IMPRINTS
  • AGOUTI LOCUS
  • GERM-CELLS
  • INHERITANCE
  • GENE
  • MICE
  • EXPRESSION

Cite this

Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., ... Whitelaw, E. (2007). Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature Genetics, 39(5), 614-622. https://doi.org/10.1038/ng2031
Chong, Suyinn ; Vickaryous, Nicola ; Ashe, Alyson ; Zamudio, Natasha ; Youngson, Neil ; Hemley, Sarah ; Stopka, Tomas ; Skoultchi, Arthur ; Matthews, Jacqui ; Scott, Hamish S. ; de Kretser, David ; O'Bryan, Moira ; Blewitt, Marnie ; Whitelaw, Emma. / Modifiers of epigenetic reprogramming show paternal effects in the mouse. In: Nature Genetics. 2007 ; Vol. 39, No. 5. pp. 614-622.
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abstract = "There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.",
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author = "Suyinn Chong and Nicola Vickaryous and Alyson Ashe and Natasha Zamudio and Neil Youngson and Sarah Hemley and Tomas Stopka and Arthur Skoultchi and Jacqui Matthews and Scott, {Hamish S.} and {de Kretser}, David and Moira O'Bryan and Marnie Blewitt and Emma Whitelaw",
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Chong, S, Vickaryous, N, Ashe, A, Zamudio, N, Youngson, N, Hemley, S, Stopka, T, Skoultchi, A, Matthews, J, Scott, HS, de Kretser, D, O'Bryan, M, Blewitt, M & Whitelaw, E 2007, 'Modifiers of epigenetic reprogramming show paternal effects in the mouse', Nature Genetics, vol. 39, no. 5, pp. 614-622. https://doi.org/10.1038/ng2031

Modifiers of epigenetic reprogramming show paternal effects in the mouse. / Chong, Suyinn; Vickaryous, Nicola; Ashe, Alyson; Zamudio, Natasha; Youngson, Neil; Hemley, Sarah; Stopka, Tomas; Skoultchi, Arthur; Matthews, Jacqui; Scott, Hamish S.; de Kretser, David; O'Bryan, Moira; Blewitt, Marnie; Whitelaw, Emma.

In: Nature Genetics, Vol. 39, No. 5, 05.2007, p. 614-622.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Hemley, Sarah

AU - Stopka, Tomas

AU - Skoultchi, Arthur

AU - Matthews, Jacqui

AU - Scott, Hamish S.

AU - de Kretser, David

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Chong S, Vickaryous N, Ashe A, Zamudio N, Youngson N, Hemley S et al. Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature Genetics. 2007 May;39(5):614-622. https://doi.org/10.1038/ng2031