Modulation of cell viability

Stephanie 斯蒂芬妮·雷纳; Albert 阿尔伯特·李; Albert 珍妮莉·戴维森; Roger 罗杰·钟

Modulation of cell viability

斯蒂芬妮·雷纳 (Inventor), 阿尔伯特·李 (Inventor), 珍妮莉·戴维森 Albert (Inventor), 罗杰·钟 (Inventor)

Macquarie University

Research output: Patent

Abstract

Provided herein are methods for enhancing the survival of neurons, for inhibiting denaturation of neurons, and for inhibiting abnormal protein accumulation in neurons, optionally motor neurons, the method comprises, consists of, or consists essentially of: increasing the level of cyclin F in the neuron regardless of the level or activity of the endogenous cyclin F of the neuron. Optionally, the neurons are in a subject suffering from or at risk of developing a neurodegenerative disease, typically a neurodegenerative disease associated with neuronal TDP-43 proteinopathy.

Original language	English
Patent number	CN114828897
IPC	C12N 15/ 86 A I
Priority date	21/10/20
Publication status	Published - 29 Jul 2022

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https://patentscope.wipo.int/search/en/detail.jsf?docId=CN371020568

1 Patent

Modulation of cellular viability
Rayner, S., Lee, A., Davidson, J. & Chung, R., 29 Apr 2021, (Submitted) IPC No. C12N 15/ 86 A I, A61K 48/00 2006.01, A61P 25/28 2006.01, Patent No. WO2021077162, Priority date 21 Oct 2019, Priority No. AU20190903956
Research output: Patent

Cite this

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title = "Modulation of cell viability",

abstract = "Provided herein are methods for enhancing the survival of neurons, for inhibiting denaturation of neurons, and for inhibiting abnormal protein accumulation in neurons, optionally motor neurons, the method comprises, consists of, or consists essentially of: increasing the level of cyclin F in the neuron regardless of the level or activity of the endogenous cyclin F of the neuron. Optionally, the neurons are in a subject suffering from or at risk of developing a neurodegenerative disease, typically a neurodegenerative disease associated with neuronal TDP-43 proteinopathy.",

author = "斯蒂芬妮·雷纳 and 阿尔伯特·李 and Albert 珍妮莉·戴维森 and 罗杰·钟",

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AU - 斯蒂芬妮·雷纳, null

AU - 阿尔伯特·李, null

AU - 珍妮莉·戴维森, Albert

AU - 罗杰·钟, null

PY - 2022/7/29

Y1 - 2022/7/29

N2 - Provided herein are methods for enhancing the survival of neurons, for inhibiting denaturation of neurons, and for inhibiting abnormal protein accumulation in neurons, optionally motor neurons, the method comprises, consists of, or consists essentially of: increasing the level of cyclin F in the neuron regardless of the level or activity of the endogenous cyclin F of the neuron. Optionally, the neurons are in a subject suffering from or at risk of developing a neurodegenerative disease, typically a neurodegenerative disease associated with neuronal TDP-43 proteinopathy.

AB - Provided herein are methods for enhancing the survival of neurons, for inhibiting denaturation of neurons, and for inhibiting abnormal protein accumulation in neurons, optionally motor neurons, the method comprises, consists of, or consists essentially of: increasing the level of cyclin F in the neuron regardless of the level or activity of the endogenous cyclin F of the neuron. Optionally, the neurons are in a subject suffering from or at risk of developing a neurodegenerative disease, typically a neurodegenerative disease associated with neuronal TDP-43 proteinopathy.

M3 - Patent

M1 - CN114828897

ER -

Modulation of cell viability

Abstract

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Research output

Modulation of cellular viability

Cite this