Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.

Original languageEnglish
Patent numberWO2021077162
IPCC12N 15/ 86 A I,A61K 48/00 2006.01,A61P 25/28 2006.01
Priority date21/10/19
Publication statusSubmitted - 29 Apr 2021


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