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Abstract
Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.
| Original language | English |
|---|---|
| Patent number | US2022362404 |
| IPC | A61K 48/ 00 A I |
| Priority date | 21/10/19 |
| Filing date | 21/10/20 |
| Publication status | Published - 17 Nov 2022 |
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Dive into the research topics of 'Modulation of cellular viability'. Together they form a unique fingerprint.Research output
- 4 Patent
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Modulation of cellular viability
Rayner, S., Lee, A., Davidson, J. & Chung, R., 31 Aug 2022, IPC No. C12N 15/ 86 A I, C12N 15/18, A61K 48/00, A01K 67/027, A61P 25/28, Patent No. EP4048320, 21 Oct 2020, Priority date 21 Oct 2019, Priority No. AU2019903956Research output: Patent
Open Access -
Modulation of cellular viability
Rayner, S., Lee, A., Davidson, J. & Chung, R., 12 May 2022, IPC No. C12N 15/ 86 A I, A61K 48/00, A61P 25/28, Patent No. AU2020369976, 21 Oct 2020, Priority date 21 Oct 2020, Priority No. WO2020AU51133Research output: Patent
Open Access -
Modulation of cellular viability
Rayner, S., Lee, A., Davidson, J. & Chung, R., 29 Apr 2021, (Submitted) IPC No. C12N 15/ 86 A I, A61K 48/00 2006.01, A61P 25/28 2006.01, Patent No. WO2021077162, Priority date 21 Oct 2019, Priority No. AU20190903956Research output: Patent