Molecular architecture of an in vivo dopamine sensor

Michael McNally, Danny Wong

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

An Carbon cylinder electrodes with small tip diameters (less than or equal to2 mum) and an appreciable surface area are ideal for the detection of such neurotransmitters in vivo. However, owing to the close half-wave potential and much higher extracellular concentration of ascorbic acid, it is often a challenge in, the electrochemical detection of the neurotransmitter dopamine in the presence of ascorbic acid. In this paper, enhanced detection of the cationic dopamine, relative to the anionic ascorbic acid, was achieved by exploiting anodically functionalised negatively charged 2,4-dinitrodiphenyl amine (in ethanol and 1,8-diazabicyclo-[5.4.0]undec-7-ene) on carbon cylinder electrodes. This resulted in the formation of an amine linkage and, speculatively, an ethanol linkage on the carbon surface. A significant feature of such a molecular architecture is that such linkages on the electrode surface are expected to be resistant to hydrolysis in aqueous solutions, further prolonging the lifetime of the electrochemical sensors. The voltammetric behaviour of both ascorbic acid and dopamine at amine/ethanol-modified carbon cylinder electrodes is presented in this paper.

Original languageEnglish
Title of host publicationSensors: Asiasense 2003 - Asian Conference On Sensors
EditorsMusa Ahmad, Lee Yook Heng, Jumat Salimon, Deepak K. Ghodgaonkar, Rabi W. Yousof, Salmijah Surif, Mohamad Nasir Taib
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages93-99
Number of pages7
ISBN (Print)0780381017
DOIs
Publication statusPublished - 2003
EventAsian Conference on Sensors - KUALA LUMPUR, Malaysia
Duration: 14 Jul 200318 Jul 2003

Conference

ConferenceAsian Conference on Sensors
CountryMalaysia
CityKUALA LUMPUR
Period14/07/0318/07/03

Keywords

  • GLASSY-CARBON ELECTRODE
  • ASCORBIC-ACID
  • BEHAVIORS

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