Molecular characterization of Lactobacillus plantarum YML016 with anti-diabetic, anti-melanogenic and anti-viral efficacy

Vivek K. Bajpai, Rajib Majumder, Irfan A. Rather, Gyeong Jun Nam, Yong Ha Park

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The present study aimed to characterize a lactic acid bacterium Lactobacillus plantarum YML016 by 16 S rRNA gene sequencing and assessing its pharmacological potential in terms of α-glucosidase and tyrosinase inhibitory effects, as well as anti-viral efficacy against human pathogenic influenza A virus H1N1 using MDCK cell line. As a result, ethanolic extract of L. plantarum YML016 exhibited α-glucosidase and tyrosinase inhibitory activities by 95.83 and 73.59%, respectively in terms of its potent anti-diabetic and anti-melanogenic potential. Moreover, YML016 displayed profound anti-cytopathic effect on MDCK cell line when treated with ethanol extract (100 mg/ml) of YML016, confirming its potent anti-viral efficacy against H1N1 influenza A virus.

LanguageEnglish
Pages301-305
Number of pages5
JournalNational Academy Science Letters
Volume41
Issue number5
DOIs
Publication statusPublished - Oct 2018
Externally publishedYes

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Viruses
Cells
Lactic acid
Bacteria
Ethanol
Genes
Glucosidases

Keywords

  • Lactobacillus plantarum YML016
  • α-Glucosidase inhibitory activity
  • tyrosinase inhibitory activity
  • anti-viral activity

Cite this

Bajpai, Vivek K. ; Majumder, Rajib ; Rather, Irfan A. ; Nam, Gyeong Jun ; Park, Yong Ha. / Molecular characterization of Lactobacillus plantarum YML016 with anti-diabetic, anti-melanogenic and anti-viral efficacy. In: National Academy Science Letters. 2018 ; Vol. 41, No. 5. pp. 301-305.
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abstract = "The present study aimed to characterize a lactic acid bacterium Lactobacillus plantarum YML016 by 16 S rRNA gene sequencing and assessing its pharmacological potential in terms of α-glucosidase and tyrosinase inhibitory effects, as well as anti-viral efficacy against human pathogenic influenza A virus H1N1 using MDCK cell line. As a result, ethanolic extract of L. plantarum YML016 exhibited α-glucosidase and tyrosinase inhibitory activities by 95.83 and 73.59{\%}, respectively in terms of its potent anti-diabetic and anti-melanogenic potential. Moreover, YML016 displayed profound anti-cytopathic effect on MDCK cell line when treated with ethanol extract (100 mg/ml) of YML016, confirming its potent anti-viral efficacy against H1N1 influenza A virus.",
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Molecular characterization of Lactobacillus plantarum YML016 with anti-diabetic, anti-melanogenic and anti-viral efficacy. / Bajpai, Vivek K.; Majumder, Rajib; Rather, Irfan A.; Nam, Gyeong Jun; Park, Yong Ha.

In: National Academy Science Letters, Vol. 41, No. 5, 10.2018, p. 301-305.

Research output: Contribution to journalArticleResearchpeer-review

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