Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii)

Teena L. Browning, Katherine Belov, Robert D. Miller, Mark D B Eldridge*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II β-chain sequences from a tammar wallaby spleen cDNA library using a tammar MHC class II β probe. These sequences belong to the marsupial MHC class II DBB gene family. Two additional DBB sequences were amplified from tammar wallaby genomic DNA. All four sequences were obtained from the same individual, indicating that there are at least two DBB loci in the tammar wallaby.

Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalImmunogenetics
Volume55
Issue number11
DOIs
Publication statusPublished - Feb 2004

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