Molecular confirmation of pathological specimen integrity in Australasia

Christopher G. Bell, Daniel R. Wood, Sarah J H Cheong, Edward Kwan, Mike Sinosich, Warick Delprado, Karl W. Baumgart

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Aim: Investigations into 14 suspected pathology sample identification errors and mix-ups were performed, as a service for several public hospital and private laboratories, from 2005 to 2007. Methods: Analyses were performed with the forensic ABI Identifiler kit of 16 microsatellites 15 autosomal and amelogenin on DNA from paraffin-embedded tissues or blood specimens and compared to independently verified single or multiple patient samples. Results: Of 23 unique patient specimens referred for sample integrity confirmation because of pathologist, clinician or patient concern, six 26.1 were demonstrated to be discordant, indicating that specimen identification errors or mix-ups had occurred. Conclusions: Due to their great sensitivity and high discrimination power, forensic identity multiplex systems using either microsatellites or single nucleotide polymorphisms SNPs can resolve concerns about pathology specimen identity and integrity.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalPathology
Volume41
Issue number3
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Human identification
  • Microsatellite
  • Sample integrity

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