Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor

Nitin Chitranshi, Vivek Gupta, Yogita Dheer, Veer Gupta, Roshana Vander Wall, Stuart Graham

Research output: Contribution to journalArticleResearchpeer-review

Abstract

TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, differentiation and maintenance. Identification of various activators and inhibitors of the TrkB receptor and greater understanding their binding mechanisms is critical to elucidate the biochemical and pharmacological pathways and analyse various protein crystallization studies. The data presented here is related to the research article entitled "Brain Derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3β (GSK3β) signalling" [1]. Cyclotraxin B (CTXB) is a disulphide bridge linked cyclic peptide molecule that interacts with TrkB receptor and inhibits the BDNF/TrkB downstream signalling. This article reports for the first time binding mechanism and interaction parameters of CTXB with the TrkB receptor. The molecular model of CTXB has been generated and it's docking with TrkB domain carried out to determine the critical residues involved in the protein peptide interaction.

LanguageEnglish
Pages776-782
Number of pages7
JournalData in Brief
Volume6
DOIs
Publication statusPublished - 1 Mar 2016

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brain
determinants
interaction
activation
regulation

Keywords

  • TrkB
  • Cyclotraxin B
  • GSK3β
  • docking

Cite this

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title = "Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor",
abstract = "TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, differentiation and maintenance. Identification of various activators and inhibitors of the TrkB receptor and greater understanding their binding mechanisms is critical to elucidate the biochemical and pharmacological pathways and analyse various protein crystallization studies. The data presented here is related to the research article entitled {"}Brain Derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3β (GSK3β) signalling{"} [1]. Cyclotraxin B (CTXB) is a disulphide bridge linked cyclic peptide molecule that interacts with TrkB receptor and inhibits the BDNF/TrkB downstream signalling. This article reports for the first time binding mechanism and interaction parameters of CTXB with the TrkB receptor. The molecular model of CTXB has been generated and it's docking with TrkB domain carried out to determine the critical residues involved in the protein peptide interaction.",
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Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor. / Chitranshi, Nitin; Gupta, Vivek; Dheer, Yogita; Gupta, Veer; Vander Wall, Roshana; Graham, Stuart.

In: Data in Brief, Vol. 6, 01.03.2016, p. 776-782.

Research output: Contribution to journalArticleResearchpeer-review

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