Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease

Tara L. Spires, Anthony J. Hannan*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

23 Citations (Scopus)

Abstract

Neurodegenerative diseases such as Huntington's disease and Alzheimer's disease, although very different in etiology, share common degenerative processes. These include neuronal dysfunction, decreased neural connectivity, and disruption of cellular plasticity. Understanding the molecular mechanisms underlying the neural plasticity deficits in these devastating conditions may lead the way toward new therapeutic targets, both disease-specific and more generalized, which can ameliorate degenerative cognitive deficits. Furthermore, investigations of 'pathological plasticity' in these diseases lend insight into normal brain function. This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities.

Original languageEnglish
Pages (from-to)874-882
Number of pages9
JournalJournal of Neurochemistry
Volume100
Issue number4
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

Keywords

  • Adult neurogenesis
  • Alzheimer's
  • Huntington's
  • Protein aggregation
  • Synaptic plasticity

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