Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

Yingchun Li; Yuan Liu; Jie Liu; Jiang Liu; Hui Tang; Cong Cao; Dongsheng Zhao; Yi Ding

doi:10.1038/srep07699

Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

Yingchun Li, Yuan Liu, Jie Liu, Jiang Liu, Hui Tang, Cong Cao, Dongsheng Zhao, Yi Ding

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Abstract

Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5 × 10⁻¹¹ to 1 × 10⁻⁹ mol L⁻¹ and 1 × 10⁻⁹ to 1.4 × 10⁻⁶ mol L⁻¹ with a remarkably low detection limit of 1.8 × 10⁻¹¹ mol L⁻¹ (S/N = 3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.

Original language	English
Article number	7699
Number of pages	8
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep07699
Publication status	Published - 9 Jan 2015
Externally published	Yes

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Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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title = "Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors",

abstract = "Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5 × 10−11 to 1 × 10−9 mol L−1 and 1 × 10−9 to 1.4 × 10−6 mol L−1 with a remarkably low detection limit of 1.8 × 10−11 mol L−1 (S/N = 3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.",

author = "Yingchun Li and Yuan Liu and Jie Liu and Jiang Liu and Hui Tang and Cong Cao and Dongsheng Zhao and Yi Ding",

note = "Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

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T1 - Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

AU - Li, Yingchun

AU - Liu, Yuan

AU - Liu, Jie

AU - Liu, Jiang

AU - Tang, Hui

AU - Cao, Cong

AU - Zhao, Dongsheng

AU - Ding, Yi

N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/1/9

Y1 - 2015/1/9

N2 - Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5 × 10−11 to 1 × 10−9 mol L−1 and 1 × 10−9 to 1.4 × 10−6 mol L−1 with a remarkably low detection limit of 1.8 × 10−11 mol L−1 (S/N = 3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.

AB - Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5 × 10−11 to 1 × 10−9 mol L−1 and 1 × 10−9 to 1.4 × 10−6 mol L−1 with a remarkably low detection limit of 1.8 × 10−11 mol L−1 (S/N = 3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.

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JF - Scientific Reports

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Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

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