Mollemycin A

an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Ritesh Raju, Zeinab G. Khalil, Andrew M. Piggott, Antje Blumenthal, Donald L. Gardiner, Tina S. Skinner-Adams, Robert J. Capon*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC 50 9 nM) clones of the malaria parasite Plasmodium falciparum.

Original languageEnglish
Pages (from-to)1716-1719
Number of pages4
JournalOrganic Letters
Volume16
Issue number6
DOIs
Publication statusPublished - 21 Mar 2014
Externally publishedYes

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