Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Ritesh Raju; Zeinab G. Khalil; Andrew M. Piggott; Antje Blumenthal; Donald L. Gardiner; Tina S. Skinner-Adams; Robert J. Capon

doi:10.1021/ol5003913

Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Ritesh Raju, Zeinab G. Khalil, Andrew M. Piggott, Antje Blumenthal, Donald L. Gardiner, Tina S. Skinner-Adams, Robert J. Capon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C₃ Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC₅₀ 10-50 nM) and drug-sensitive (3D7; IC₅₀ 7 nM) and multidrug-resistant (Dd2; IC ₅₀ 9 nM) clones of the malaria parasite Plasmodium falciparum.

Original language	English
Pages (from-to)	1716-1719
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	6
DOIs	https://doi.org/10.1021/ol5003913
Publication status	Published - 21 Mar 2014
Externally published	Yes

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title = "Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)",

abstract = "A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC 50 9 nM) clones of the malaria parasite Plasmodium falciparum.",

author = "Ritesh Raju and Khalil, {Zeinab G.} and Piggott, {Andrew M.} and Antje Blumenthal and Gardiner, {Donald L.} and Skinner-Adams, {Tina S.} and Capon, {Robert J.}",

year = "2014",

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doi = "10.1021/ol5003913",

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AU - Raju, Ritesh

AU - Khalil, Zeinab G.

AU - Piggott, Andrew M.

AU - Blumenthal, Antje

AU - Gardiner, Donald L.

AU - Skinner-Adams, Tina S.

AU - Capon, Robert J.

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AB - A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC 50 9 nM) clones of the malaria parasite Plasmodium falciparum.

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Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

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