MONITORING OF CANINE PANCREAS ALLOGRAFT FUNCTION WITH MEASUREMENTS OF URINARY AMYLASE

H. Ekberg, S. A. Deane*, R. D M Allen, W. J. Hawthorne, P. Williamson, J. M. Grierson, G. J. Stewart, J. M. Little

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A canine model of whole pancreas transplantation with pancreaticocystostomy was studied for predictability of graft rejection using urinary amylase (UA) monitoring. Six pancreatectomized dogs were transplanted without immunosuppression and with acute rejection occurring at a median of 9.5 days (range 7–12 days). A differential loss of allograft exocrine and endocrine function was demonstrated. with a gradual decrease in UA after transplantation but maintenance of fasting blood glucose levels (FBGL) till the day before complete loss of graft structure. Another 13 dogs treated with cyclosporin (25 mg/kg per day) had prolonged graft survival (P < 0.01) with an actuarial median survival of 91 days (range 8–159 days). Five allografts were lost because of rejection and eight dogs died with functioning grafts. Fasting spot levels of UA < 5000 iu/l or < 10000 iu/l had a positive predictivity of graft failure of 71% or 31%, respectively. Falls of UA levels of greater than 75% in 24 h and 48 h were seen equally in both rejecting and functioning allografts. This study confirmed the role of UA as an earlier marker of rejection than FBGL. The clinical role of UA will be important, but its use as a predictor of pancreas rejection may be dependent on a fall to a predetermined level rather than the rate of fall.

Original languageEnglish
Pages (from-to)583-586
Number of pages4
JournalAustralian and New Zealand Journal of Surgery
Volume58
Issue number7
DOIs
Publication statusPublished - 1988
Externally publishedYes

Keywords

  • cyclosporin
  • diagnosis
  • pancreas transplantation
  • rejection
  • urinary amylase.

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