Mortality in mild cognitive impairment: a longitudinal study in memory clinics

Michael H. Connors, David Ames, Karyn Boundy, Roger Clarnette, Sue Kurrle, Alastair Mander, John Ward, Michael Woodward, Henry Brodaty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background: Patients with mild cognitive impairment (MCI) are at greater risk of mortality than the general population. Comparatively little research has examined predictors of mortality in MCI and no research has examined whether time-varying variables, such as change in cognition and function, predict survival. Objective: To identify predictors of mortality in patients with MCI. Methods: 185 patients with MCI were recruited from nine memory clinics around Australia. Patients completed measures of cognition, function, and neuropsychiatric symptoms over three years. Mortality data were obtained from state registries eight years after baseline. Results: 55 (30%) patients died within this period. Older age, lower cognitive and functional ability at baseline, and greater decline in functional ability over six months predicted mortality. Conclusion: Easily measurable clinical data predict mortality in patients with MCI. Longitudinal assessment over time can provide additional information about patients' risk.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalJournal of Alzheimer's Disease
Issue number1
Publication statusPublished - 23 Aug 2016
Externally publishedYes


  • Lifespan
  • Longitudinal studies
  • Mild cognitive impairment
  • Mortality
  • Risk factors
  • Survival


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