Motion representation of ciliated cell images with contour-alignment for automated CBF estimation

Fan Zhang, Yang Song, Siqi Liu, Paul Young, Daniela Traini, Lucy Morgan, Hui-Xin Ong, Lachlan Buddle, Sidong Liu, Dagan Feng, Weidong Cai

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

Ciliary beating frequency (CBF) estimation is of high interest for the diagnosis and therapeutic assessment of defective mucociliary clearance diseases. Image-based methods have recently become the focus of accurate CBF measurement. The influence from the moving ciliated cell however makes the processing a challenging problem. In this work, we present a registration method for cell movement alignment, based on cell contour segmentation. We also propose a filter feature-based ciliary motion representation, which can better characterize the periodical changes of beating cilia. Experimental results on microscopic time sequence human primary ciliated cell images show the accuracy of our method for CBF computation.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2015
Subtitle of host publication18th International Conference : Munich, Germany, October 5-9, 2015 : proceedings, part III
EditorsNassir Navab, Joachim Hornegger, William M. Wells, Alejandro F. Frangi
Place of PublicationCham
PublisherSpringer, Springer Nature
Pages300-307
Number of pages8
ISBN (Electronic)9783319245744
ISBN (Print)9783319245737
DOIs
Publication statusPublished - 2015
Externally publishedYes
Event18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 5 Oct 20159 Oct 2015

Publication series

NameLecture notes in computer science
PublisherSpringer International Publishing AG Switzerland
Volume9351
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015
CountryGermany
CityMunich
Period5/10/159/10/15

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