Motor-language coupling in Huntington's disease families

Lucila Kargieman, Eduar Herrera, Sandra Baez, Adolfo M. García, Martin Dottori, Carlos Gelormini, Facundo Manes, Oscar Gershanik, Agustín Ibáñez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
5 Downloads (Pure)

Abstract

Traditionally, Huntington's disease (HD) has been known as a movement disorder, characterized by motor, psychiatric, and cognitive impairments. Recent studies have shown that motor and action-language processes are neurally associated. The cognitive mechanisms underlying this interaction have been investigated through the action compatibility effect (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and verbal processing. The present study is the first to use the ACE paradigm to evaluate action-word processing in HD patients (HDP) and their families. Specifically, we tested three groups: HDP, healthy first-degree relatives (HDR), and non-relative healthy controls. The results showed that ACE was abolished in HDP as well as HDR, but not in controls. Furthermore, we found that the processing deficits were primarily linguistic, given that they did not correlate executive function measurements. Our overall results underscore the role of cortico-basal ganglia circuits in action-word processing and indicate that the ACE task is a sensitive and robust early biomarker of HD and familial vulnerability.

Original languageEnglish
Article number122
Pages (from-to)1-12
Number of pages12
JournalFrontiers in Aging Neuroscience
Volume6
Issue numberJUN
DOIs
Publication statusPublished - 12 Jun 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • ACE
  • Action-language
  • Familial vulnerability
  • Huntington's disease
  • KDT
  • Motor-language coupling

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