Motor neuron susceptibility in ALS/FTD

Audrey M. G. Ragagnin, Sina Shadfar, Marta Vidal, Md Shafi Jamali, Julie D. Atkin

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord. The neurodegenerative mechanisms leading to MN loss in ALS are not fully understood. Importantly, the reasons why MNs are specifically targeted in this disorder are unclear, when the proteins associated genetically or pathologically with ALS are expressed ubiquitously. Furthermore, MNs themselves are not affected equally; specific MNs subpopulations are more susceptible than others in both animal models and human patients. Corticospinal MNs and lower somatic MNs, which innervate voluntary muscles, degenerate more readily than specific subgroups of lower MNs, which remain resistant to degeneration, reflecting the clinical manifestations of ALS. In this review, we discuss the possible factors intrinsic to MNs that render them uniquely susceptible to neurodegeneration in ALS. We also speculate why some MN subpopulations are more vulnerable than others, focusing on both their molecular and physiological properties. Finally, we review the anatomical network and neuronal microenvironment as determinants of MN subtype vulnerability and hence the progression of ALS.

LanguageEnglish
Article number532
Pages1-37
Number of pages37
JournalFrontiers in Neuroscience
Volume13
Issue numberJUN
DOIs
Publication statusPublished - 27 Jun 2019

Fingerprint

Amyotrophic Lateral Sclerosis
Motor Neurons
Intrinsic Factor
Neurodegenerative Diseases
Brain Stem
Spinal Cord
Skeletal Muscle
Animal Models

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Amyotrophic lateral sclerosis
  • Fast and slow motor units
  • Frontotemporal dementia
  • Neurodegeneration
  • Selective vulnerability

Cite this

Ragagnin, Audrey M. G. ; Shadfar, Sina ; Vidal, Marta ; Jamali, Md Shafi ; Atkin, Julie D. / Motor neuron susceptibility in ALS/FTD. In: Frontiers in Neuroscience. 2019 ; Vol. 13, No. JUN. pp. 1-37.
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Motor neuron susceptibility in ALS/FTD. / Ragagnin, Audrey M. G.; Shadfar, Sina; Vidal, Marta; Jamali, Md Shafi; Atkin, Julie D.

In: Frontiers in Neuroscience, Vol. 13, No. JUN, 532, 27.06.2019, p. 1-37.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Ragagnin,Audrey M. G.

AU - Shadfar,Sina

AU - Vidal,Marta

AU - Jamali,Md Shafi

AU - Atkin,Julie D.

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Y1 - 2019/6/27

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