Motor neuroplasticity

a MEG-fMRI study of motor imagery and execution in healthy ageing

Hana Burianová*, Lars Marstaller, Anina N. Rich, Mark A. Williams, Greg Savage, Margaret Ryan, Paul F. Sowman

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Age-related decline in motor function is associated with over-activation of the sensorimotor circuitry. Using a multimodal MEG-fMRI paradigm, we investigated whether this neural over-recruitment in old age would be related to changes in movement-related beta desynchronization (MRBD), a correlate of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), and whether it would characterize compensatory recruitment or a reduction in neural specialization (dedifferentiation). We used MEG to assess age-related changes in beta band oscillations in primary motor cortices, fMRI to localize age-related changes in brain activity, and the Finger Configuration Task to measure task performance during overt and covert motor processing: motor execution (ME) and motor imagery (MI). The results are threefold: first, showing age-related neuroplasticity during ME of older adults, compared to young adults, as evidenced by increased MRBD in motor cortices and over-recruitment of sensorimotor areas; second, showing similar age-related neuroplastic changes during MI; and finally, showing signs of dedifferentiation during ME in older adults whose performance negatively correlated with connectivity to bilateral primary motor cortex. Together, these findings demonstrate that elevated MRBD levels, reflecting greater GABAergic inhibitory activity, and over-activation of the sensorimotor network during ME may not be compensatory, but rather might reflect an age-related decline of the quality of the underlying neural signal.

Original languageEnglish
Article number107539
Pages (from-to)1-9
Number of pages9
JournalNeuropsychologia
Volume146
Early online date3 Jul 2020
DOIs
Publication statusPublished - Sep 2020

Keywords

  • ageing
  • compensation
  • dedifferentiation
  • motor execution
  • motor imagery

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