Mouse brain glycomics – Insights from exploring the Allen Brain Atlas and the implications for the neuroimmune brain

Edward S. X. Moh; Sagar Dalal; Mark R. Hutchinson; Nicolle H. Packer

doi:10.1016/j.bbi.2023.06.024

Mouse brain glycomics – Insights from exploring the Allen Brain Atlas and the implications for the neuroimmune brain

Edward S. X. Moh, Sagar Dalal, Mark R. Hutchinson, Nicolle H. Packer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The Allen Institute Mouse Brain Atlas, with visualisation using the Brain Explorer software, offers a 3-dimensional view of region-specific RNA expression of thousands of mouse genes. In this Viewpoint, we focused on the region-specific expression of genes related to cellular glycosylation, and discuss their relevance towards psychoneuroimmunology. Using specific examples, we show that the Atlas validates existing observations reported by others, identifies previously unknown potential region-specific glycan features, and highlights the need to promote collaborations between glycobiology and psychoneuroimmunology researchers.

Original language	English
Pages (from-to)	83-90
Number of pages	8
Journal	Brain, Behavior, and Immunity
Volume	113
Early online date	30 Jun 2023
DOIs	https://doi.org/10.1016/j.bbi.2023.06.024
Publication status	Published - Oct 2023

Keywords

Glycosylation
Allen Brain
region-specific
psychoneuroimmunology
Data mining
Region-specific
Psychoneuroimmunology

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10.1016/j.bbi.2023.06.024

Cite this

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title = "Mouse brain glycomics – Insights from exploring the Allen Brain Atlas and the implications for the neuroimmune brain",

abstract = "The Allen Institute Mouse Brain Atlas, with visualisation using the Brain Explorer software, offers a 3-dimensional view of region-specific RNA expression of thousands of mouse genes. In this Viewpoint, we focused on the region-specific expression of genes related to cellular glycosylation, and discuss their relevance towards psychoneuroimmunology. Using specific examples, we show that the Atlas validates existing observations reported by others, identifies previously unknown potential region-specific glycan features, and highlights the need to promote collaborations between glycobiology and psychoneuroimmunology researchers.",

keywords = "Glycosylation, Allen Brain, region-specific, psychoneuroimmunology, Data mining, Region-specific, Psychoneuroimmunology",

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AU - Moh, Edward S. X.

AU - Dalal, Sagar

AU - Hutchinson, Mark R.

AU - Packer, Nicolle H.

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AB - The Allen Institute Mouse Brain Atlas, with visualisation using the Brain Explorer software, offers a 3-dimensional view of region-specific RNA expression of thousands of mouse genes. In this Viewpoint, we focused on the region-specific expression of genes related to cellular glycosylation, and discuss their relevance towards psychoneuroimmunology. Using specific examples, we show that the Atlas validates existing observations reported by others, identifies previously unknown potential region-specific glycan features, and highlights the need to promote collaborations between glycobiology and psychoneuroimmunology researchers.

KW - Glycosylation

KW - Allen Brain

KW - region-specific

KW - psychoneuroimmunology

KW - Data mining

KW - Region-specific

KW - Psychoneuroimmunology

UR - http://purl.org/au-research/grants/arc/CE200100029

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JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

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Mouse brain glycomics – Insights from exploring the Allen Brain Atlas and the implications for the neuroimmune brain

Abstract

Keywords

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COESB: ARC Centre of Excellence in Synthetic Biology

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Mouse brain glycomics – Insights from exploring the Allen Brain Atlas and the implications for the neuroimmune brain

Abstract

Keywords

Access to Document

Other files and links

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Projects

COESB: ARC Centre of Excellence in Synthetic Biology

Cite this