Mouse cellular cementum is highly dependent on growth hormone status

J. R. Smid*, J. E. Rowland, W. G. Young, T. J. Daley, K. T. Coschigano, J. J. Kopchick, M. J. Waters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Cementum is known to be growth-hormone (GH) -responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p < 0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalJournal of Dental Research
Volume83
Issue number1
Publication statusPublished - Jan 2004
Externally publishedYes

Keywords

  • Cementum
  • GH receptor knockout mice
  • GH transgenic mice
  • Growth hormone

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