Mouse mammary tumor virus-like sequences in human breast cancer

James S. Lawson, Wendy K. Glenn, Brian Salmons, Yulan Ye, Benjamin Heng, Patrick Moody, Harpreet Johal, William D. Rawlinson, Warick Delprado, Louise Lutze-Mann, Noel J. Whitaker

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Mouse mammary tumor virus (MMTV) sequences have been reported to be present in some human breast cancers, but it is unclear whether they have any causal role. In mice, MMTV promotes tumor formation indirectly by insertional mutagenesis of Wnt oncogenes that lead to their activation. In this study, we investigated the status of Wnt-1 in human breast cancers harboring MMTV-like sequences encoding viral envelope (env) genes. We confirmed the detection of env sequences in the nucleus of human breast cancer specimens that are similar in appearance to mouse mammary tumors expressing MMTV env sequences. MMTV env sequences in human breast cancers were also nearly indistinguishable from env sequences in mouse MMTV isolates. Further, Wnt-1 expression was higher in specimens of env-positive ductal carcinoma in situ and invasive ductal carcinoma, relative to env-negative specimens. Our findings extend the evidence that MMTV sequences found in naturally occurring mouse mammary tumors can be found in some human breast cancers, prompting further evaluation of causal roles in these settings.

Original languageEnglish
Pages (from-to)3576-3585
Number of pages10
JournalCancer Research
Volume70
Issue number9
DOIs
Publication statusPublished - 1 May 2010
Externally publishedYes

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