Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions

Liting Deng, Vivek Gupta, Yunqi Wu, Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Veer B. Gupta, Matthew J. Fitzhenry, Masoud Zabet Moghaddam, Tim Karl, Ghassem Hosseini Salekdeh, Stuart L. Graham, Paul A. Haynes, Mehdi Mirzaei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.

Original languageEnglish
Article number2000213
Number of pages7
JournalProteomics
Early online date9 Feb 2021
DOIs
Publication statusE-pub ahead of print - 9 Feb 2021

Keywords

  • Alzheimer’s disease, proteomics, hippocampus, cortex, cerebellum, amyloid beta, APP/PS1
  • cortex
  • hippocampus
  • proteomics
  • APP/PS1
  • Alzheimer's disease
  • amyloid beta
  • cerebellum

Fingerprint Dive into the research topics of 'Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions'. Together they form a unique fingerprint.

Cite this