Mouse moler dentin size/shape is dependent on growth hormone status

J. R. Smid*, J. E. Rowland, W. G. Young, K. T. Coschigano, J. J. Kopchick, M. J. Waters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Growth hormone (GH) status affects dental development, but how GH influences tooth size/shape is unclear. Since GH affects dental epithelial proliferation, we hypothesized that GH influences the tooth crown and root dimensions. Dentin matrix dimensions were measured in longitudinal sections of decalcified first mandibular molars from 3 genetically modified mice: giant (GH-Excess) mice and dwarf (GHAntagonist and GH-Receptor-Knockout) mice. GH status was found to influence crown width, root length, and dentin thickness. Analysis of these data suggests that GH influences both tooth crown and root development prior to dentinogenesis as well as during appositional growth of dentin. This is concordant with the expression of paracrine GH and GH receptors during tooth bud morphogenesis, and of GH receptors in the enamel organ, dental papilla, and Hertwig's epithelial root sheath during dentinogenesis. Based on prior studies, these GH morphogenetic actions may be mediated by the induction of both bone morphogenetic protein and insulin-like growth factor-1 expression.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalJournal of Dental Research
Issue number5
Publication statusPublished - May 2007
Externally publishedYes


  • Dentin dimensions
  • GH receptor-knockout mice
  • GH transgenic mice
  • Growth hormone
  • Tooth morphogenesis


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