TY - JOUR
T1 - MPID
T2 - MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules
AU - Govindarajan, Kunde Ramamoorthy
AU - Kangueane, Pandjassarame
AU - Tan, Tin Wee
AU - Ranganathan, Shoba
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.
AB - Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.
UR - http://www.scopus.com/inward/record.url?scp=0037314055&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/19.2.309
DO - 10.1093/bioinformatics/19.2.309
M3 - Article
C2 - 12538264
AN - SCOPUS:0037314055
VL - 19
SP - 309
EP - 310
JO - Bioinformatics
JF - Bioinformatics
SN - 1367-4803
IS - 2
ER -