Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

Chloe Duffield, Laura Rey Gomez, Su Su Thae Hnit, Wei Zhang, Simon Tsao, David Inglis, Yuling Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (p = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.
Original languageEnglish
Pages (from-to)8915–8918
Number of pages4
JournalChemical Communications
Volume61
Issue number49
Early online date21 May 2025
DOIs
Publication statusPublished - 21 Jun 2025

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