Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

Chloe Duffield; Laura Rey Gomez; Su Su Thae Hnit; Wei Zhang; Simon Tsao; David Inglis; Yuling Wang

doi:10.1039/D5CC01038A

Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

Chloe Duffield
, Laura Rey Gomez
, Su Su Thae Hnit
, Wei Zhang
, Simon Tsao
, David Inglis
, Yuling Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (p = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.

Original language	English
Pages (from-to)	8915–8918
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	49
Early online date	21 May 2025
DOIs	https://doi.org/10.1039/D5CC01038A
Publication status	Published - 21 Jun 2025

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10.1039/D5CC01038A

https://pubs.rsc.org/en/Content/ArticleLanding/2025/CC/D5CC01038A

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title = "Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles",

abstract = "Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (p = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.",

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T1 - Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

AU - Duffield, Chloe

AU - Rey Gomez, Laura

AU - Hnit, Su Su Thae

AU - Zhang, Wei

AU - Tsao, Simon

AU - Inglis, David

AU - Wang, Yuling

PY - 2025/6/21

Y1 - 2025/6/21

N2 - Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (p = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.

AB - Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (p = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.

UR - https://www.scopus.com/pages/publications/105005882401

UR - https://purl.org/au-research/grants/arc/FT210100737

U2 - 10.1039/D5CC01038A

DO - 10.1039/D5CC01038A

M3 - Article

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VL - 61

SP - 8915

EP - 8918

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

Abstract

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