Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Nial J. Wheate; Anthony I. Day; Rodney J. Blanch; Alan P. Arnold; Carleen Cullinane; J. Grant Collins

doi:10.1039/b404358h

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Nial J. Wheate, Anthony I. Day, Rodney J. Blanch, Alan P. Arnold, Carleen Cullinane, J. Grant Collins

Research output: Contribution to journal › Article › peer-review

163 Citations (Scopus)

Abstract

The dinuclear platinum complex trans-[{Pt(NH₃)₂Cl}₂μ-dpzm]²⁺ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

Original language	English
Pages (from-to)	1424-1425
Number of pages	2
Journal	Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/b404358h
Publication status	Published - 21 Jun 2004
Externally published	Yes

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10.1039/b404358h

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title = "Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment",

abstract = "The dinuclear platinum complex trans-[\{Pt(NH3)2Cl\}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.",

author = "Wheate, \{Nial J.\} and Day, \{Anthony I.\} and Blanch, \{Rodney J.\} and Arnold, \{Alan P.\} and Carleen Cullinane and Collins, \{J. Grant\}",

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doi = "10.1039/b404358h",

language = "English",

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AU - Wheate, Nial J.

AU - Day, Anthony I.

AU - Blanch, Rodney J.

AU - Arnold, Alan P.

AU - Cullinane, Carleen

AU - Collins, J. Grant

PY - 2004/6/21

Y1 - 2004/6/21

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AB - The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

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JF - Chemical Communications

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Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Abstract

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