This paper presents a new method for exon detection in DNA sequences based on multi-scale parametric spectral analysis. A forward-backward linear prediction (FBLP) with the singular value decomposition (SVD) algorithm FBLP-SVD is applied to the double-base curves (DB-curves) of a DNA sequence using a variable moving window sizes to estimate the signal spectrum at multiple scales. Simulations are done on short human genes in the range of 11bp to 2032bp and the results show that our proposed method out-performs the classical Fourier transform method. The multi-scale approach is shown to be more effective than using a single scale with a fixed window size. In addition, our method is flexible as it requires no training data.
|Number of pages||6|
|Publication status||Published - 12 Feb 2008|
Bibliographical noteCopyright the Author(s) 2008. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
- Journal Article