Multi-Shell UiO-66-NH₂ adsorbents via Micelle-Directed assembly for adenosine recognition and separation

Efficient and selective separation of biologically important adenosine derivatives remains a critical challenge. While traditional methods have limitations, adsorption offers distinct advantages including simplicity, environmental friendliness, and high efficiency. We developed hierarchical multi-shelled UiO-66-NH₂ microspheres through a micelle-directed strategy, incorporating fluorinated ligands (BDC-F) to enhance performance. The resulting 1F-UiO-66-NH₂ material demonstrated exceptional adsorption capabilities for adenosine monophosphate (AMP), achieving a capacity of 767.51 μmol·g⁻¹ at 298 K with rapid adsorption kinetics. Importantly, the material maintained robust performance, retaining > 75 % efficiency after five adsorption–desorption cycles while showing excellent selectivity in complex biological matrices of spiked human urine. These findings establish the potential of structurally engineered MOFs for advanced bioseparation applications, combining high capacity with operational stability.