Multidrug efflux pumps and resistance: Regulation and evolution

Ian T. Paulsen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

169 Citations (Scopus)


Multidrug transporters have long puzzled researchers because of their ability to extrude multiple structurally dissimilar toxic chemotherapeutic agents. They appear to be essentially ubiquitous with many microorganisms possessing large arsenals of predicted multidrug efflux transporters. Recent reports on the structures of multidrug efflux transporters and their cognate regulators have suggested that the basis of multidrug recognition is the presence of large flexible hydrophobic cavities capable of accommodating different compounds that are bound via hydrogen bonding and/or electrostatic interactions. This structural data provides the context for understanding other questions about the evolution of multidrug transporters and their natural physiological roles.

Original languageEnglish
Pages (from-to)446-451
Number of pages6
JournalCurrent Opinion in Microbiology
Issue number5
Publication statusPublished - Oct 2003
Externally publishedYes


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