Multidrug Resistance Plasmid pSK108 from Coagulase-Negative Staphylococci; Relationships to Staphylococcus aureus qacC Plasmids

Amornrut Leelaporn*, Neville Firth, Ian T. Paulsen, Anusha Hettiaratchi, Ronald A. Skurray

*Corresponding author for this work

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The 2.4-kb Staphylococcus epidermidis plasmid. pSK108, encodes a qacC multidrug resistance determinant. Sequence analysis has revealed that pSK108 is a member of the pC194 family of rolling circle replicating plasmids and suggests that the DNA segment containing qacC, which is bounded by the replication nick site and the minus origin palA, represents a resistance gene cassette that has undergone horizontal genetic exchange.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalPlasmid
Volume34
Issue number1
DOIs
Publication statusPublished - Jul 1995
Externally publishedYes

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