Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy

Jonas Graf; Lea Jansen; Jens Ingwersen; Marius Ringelstein; Jens Harmel; Jana Rybak; Robert Kolbe; Laura Rhose; Lena Gemerzki; John-Ih Lee; Alexander Klistorner; Rainer Guthoff; Hans-Peter Hartung; Orhan Aktas; Philipp Albrecht

doi:10.1002/acn3.593

Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy

Jonas Graf, Lea Jansen, Jens Ingwersen, Marius Ringelstein, Jens Harmel, Jana Rybak, Robert Kolbe, Laura Rhose, Lena Gemerzki, John-Ih Lee, Alexander Klistorner, Rainer Guthoff, Hans-Peter Hartung, Orhan Aktas, Philipp Albrecht

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Abstract

Objective: Studies using conventional full‐field visual evoked potentials (ffVEP) have reported subtle abnormalities in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesize that these abnormalities can be detected in the majority of CIDP patients using enhanced methods.

Methods: We performed a cross‐sectional noninterventional study comparing 18 CIDP patients and 18 matched healthy controls using multifocal VEP (mfVEP) as a technique with enhanced sensitivity to detect conduction abnormalities across the spectrum of optic nerve fibers. Patients with confounding diseases (ophthalmologic, diabetes mellitus) were excluded.

Results: The mean amplitude and latency, as well as the low‐contrast visual acuity, did not differ between CIDP patients and controls. Subanalyses revealed latency differences concerning the superior sector of the visual field. Severity markers of CIDP (ODSS, motor nerve conduction velocity) were associated with mfVEP latency delay.

Interpretation: We could not adduce evidence for clinically or diagnostically relevant visual pathway involvement in CIDP. The latency differences identified were very subtle and restricted to the superior visual field which cannot be readily explained biologically, anatomically, or pathologically. In summary, we conclude that our study revealed no relevant differences in mfVEP parameters between CIDP patients and controls.

Original language	English
Pages (from-to)	952-961
Number of pages	10
Journal	Annals of Clinical and Translational Neurology
Volume	5
Issue number	8
DOIs	https://doi.org/10.1002/acn3.593
Publication status	Published - Aug 2018
Externally published	Yes

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Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Graf, J., Jansen, L., Ingwersen, J., Ringelstein, M., Harmel, J., Rybak, J., Kolbe, R., Rhose, L., Gemerzki, L., Lee, J.-I., Klistorner, A., Guthoff, R., Hartung, H.-P., Aktas, O., & Albrecht, P. (2018). Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy. Annals of Clinical and Translational Neurology, 5(8), 952-961. https://doi.org/10.1002/acn3.593

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title = "Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy",

abstract = "Objective: Studies using conventional full‐field visual evoked potentials (ffVEP) have reported subtle abnormalities in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesize that these abnormalities can be detected in the majority of CIDP patients using enhanced methods. Methods: We performed a cross‐sectional noninterventional study comparing 18 CIDP patients and 18 matched healthy controls using multifocal VEP (mfVEP) as a technique with enhanced sensitivity to detect conduction abnormalities across the spectrum of optic nerve fibers. Patients with confounding diseases (ophthalmologic, diabetes mellitus) were excluded. Results: The mean amplitude and latency, as well as the low‐contrast visual acuity, did not differ between CIDP patients and controls. Subanalyses revealed latency differences concerning the superior sector of the visual field. Severity markers of CIDP (ODSS, motor nerve conduction velocity) were associated with mfVEP latency delay. Interpretation: We could not adduce evidence for clinically or diagnostically relevant visual pathway involvement in CIDP. The latency differences identified were very subtle and restricted to the superior visual field which cannot be readily explained biologically, anatomically, or pathologically. In summary, we conclude that our study revealed no relevant differences in mfVEP parameters between CIDP patients and controls.",

author = "Jonas Graf and Lea Jansen and Jens Ingwersen and Marius Ringelstein and Jens Harmel and Jana Rybak and Robert Kolbe and Laura Rhose and Lena Gemerzki and John-Ih Lee and Alexander Klistorner and Rainer Guthoff and Hans-Peter Hartung and Orhan Aktas and Philipp Albrecht",

note = "Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2018",

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Graf, J, Jansen, L, Ingwersen, J, Ringelstein, M, Harmel, J, Rybak, J, Kolbe, R, Rhose, L, Gemerzki, L, Lee, J-I, Klistorner, A, Guthoff, R, Hartung, H-P, Aktas, O & Albrecht, P 2018, 'Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy', Annals of Clinical and Translational Neurology, vol. 5, no. 8, pp. 952-961. https://doi.org/10.1002/acn3.593

TY - JOUR

T1 - Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy

AU - Graf, Jonas

AU - Jansen, Lea

AU - Ingwersen, Jens

AU - Ringelstein, Marius

AU - Harmel, Jens

AU - Rybak, Jana

AU - Kolbe, Robert

AU - Rhose, Laura

AU - Gemerzki, Lena

AU - Lee, John-Ih

AU - Klistorner, Alexander

AU - Guthoff, Rainer

AU - Hartung, Hans-Peter

AU - Aktas, Orhan

AU - Albrecht, Philipp

N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2018/8

Y1 - 2018/8

N2 - Objective: Studies using conventional full‐field visual evoked potentials (ffVEP) have reported subtle abnormalities in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesize that these abnormalities can be detected in the majority of CIDP patients using enhanced methods. Methods: We performed a cross‐sectional noninterventional study comparing 18 CIDP patients and 18 matched healthy controls using multifocal VEP (mfVEP) as a technique with enhanced sensitivity to detect conduction abnormalities across the spectrum of optic nerve fibers. Patients with confounding diseases (ophthalmologic, diabetes mellitus) were excluded. Results: The mean amplitude and latency, as well as the low‐contrast visual acuity, did not differ between CIDP patients and controls. Subanalyses revealed latency differences concerning the superior sector of the visual field. Severity markers of CIDP (ODSS, motor nerve conduction velocity) were associated with mfVEP latency delay. Interpretation: We could not adduce evidence for clinically or diagnostically relevant visual pathway involvement in CIDP. The latency differences identified were very subtle and restricted to the superior visual field which cannot be readily explained biologically, anatomically, or pathologically. In summary, we conclude that our study revealed no relevant differences in mfVEP parameters between CIDP patients and controls.

AB - Objective: Studies using conventional full‐field visual evoked potentials (ffVEP) have reported subtle abnormalities in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesize that these abnormalities can be detected in the majority of CIDP patients using enhanced methods. Methods: We performed a cross‐sectional noninterventional study comparing 18 CIDP patients and 18 matched healthy controls using multifocal VEP (mfVEP) as a technique with enhanced sensitivity to detect conduction abnormalities across the spectrum of optic nerve fibers. Patients with confounding diseases (ophthalmologic, diabetes mellitus) were excluded. Results: The mean amplitude and latency, as well as the low‐contrast visual acuity, did not differ between CIDP patients and controls. Subanalyses revealed latency differences concerning the superior sector of the visual field. Severity markers of CIDP (ODSS, motor nerve conduction velocity) were associated with mfVEP latency delay. Interpretation: We could not adduce evidence for clinically or diagnostically relevant visual pathway involvement in CIDP. The latency differences identified were very subtle and restricted to the superior visual field which cannot be readily explained biologically, anatomically, or pathologically. In summary, we conclude that our study revealed no relevant differences in mfVEP parameters between CIDP patients and controls.

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U2 - 10.1002/acn3.593

DO - 10.1002/acn3.593

M3 - Article

C2 - 30128319

SN - 2328-9503

VL - 5

SP - 952

EP - 961

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 8

ER -

Multifocal visual evoked potentials in chronic inflammatory demyelinating polyneuropathy

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