Multifunctional chiral aminophosphines for enantiodivergent catalysis in a palladium-catalyzed allylic alkylation reaction

Sviatoslav S. Eliseenko, Mohan Bhadbhade, Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Trifunctional MAP-based chiral phosphines were tested as new ligands in a Pd-catalyzed asymmetric allylic alkylation, demonstrating fast and enantiodivergent catalysis. The palladium complexes of representative ligands by X-ray analysis revealed a novel mode of P,N-coordination of the ligand to the palladium center, which may contribute to switching the sense of the asymmetric induction via combined steric and tunable H-bonding interactions between the metal complex and the substrates.

Original languageEnglish
Pages (from-to)1311-1323
Number of pages13
JournalChirality
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 2020

Keywords

  • catalytic dualism
  • enantiodivergent catalysis
  • H-bonding ligands

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