Multifunctional glucose biosensors from Fe3O4 nanoparticles modified chitosan/graphene nanocomposites

Wenjing Zhang, Xiaojian Li, Ruitao Zou, Huizi Wu, Haiyan Shi, Shanshan Yu, Yong Liu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    95 Citations (Scopus)
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    Abstract

    Novel water-dispersible and biocompatible chitosan-functionalized graphene (CG) has been prepared by a one-step ball milling of carboxylic chitosan and graphite. Presence of nitrogen (from chitosan) at the surface of graphene enables the CG to be an outstanding catalyst for the electrochemical biosensors. The resulting CG shows lower I D /I G ratio in the Raman spectrum than other nitrogen-containing graphene prepared using different techniques. Magnetic Fe3O4 nanoparticles (MNP) are further introduced into the as-synthesized CG for multifunctional applications beyond biosensors such as magnetic resonance imaging (MRI). Carboxyl groups from CG is used to directly immobilize glucose oxidase (GO x) via covalent linkage while incorporation of MNP further facilitated enzyme loading and other unique properties. The resulting biosensor exhibits a good glucose detection response with a detection limit of 16μM, a sensitivity of 5.658mA/cm 2 /M, and a linear detection range up to 26mM glucose. Formation of the multifunctional MNP/CG nanocomposites provides additional advantages for applications in more clinical areas such as in vivo biosensors and MRI agents.

    Original languageEnglish
    Article number11129
    Pages (from-to)1-9
    Number of pages9
    JournalScientific Reports
    Volume5
    DOIs
    Publication statusPublished - 8 Jun 2015

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