Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons

Bingyang Shi*, Xin Du, Jian Chen, Libing Fu, Marco Morsch, Albert Lee, Yong Liu, Nicholas Cole, Roger Chung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain-disease therapy, a drug delivery system that can sustainably control drug-release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light-traceable and intracellular microenvironment-responsive drug delivery system was developed based on the combination of glutathione-responsive autoflurescent nanogel, dendrimer-like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage-release of sulfydryl-containing drugs into neurons, with light-traceable monitoring for future brain-disease therapy.

Original languageEnglish
Article number1603966
Pages (from-to)1-10
Number of pages10
JournalSmall
Volume13
Issue number20
DOIs
Publication statusPublished - 24 May 2017

Keywords

  • Multistage controlled release
  • Neurons
  • Responsive drug delivery
  • Sulfydryl-containing drugs
  • Traceable drug delivery

Fingerprint Dive into the research topics of 'Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons'. Together they form a unique fingerprint.

Cite this