Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons

Bingyang Shi; Xin Du; Jian Chen; Libing Fu; Marco Morsch; Albert Lee; Yong Liu; Nicholas Cole; Roger Chung

doi:10.1002/smll.201603966

Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons

Bingyang Shi^*, Xin Du, Jian Chen, Libing Fu, Marco Morsch, Albert Lee, Yong Liu, Nicholas Cole, Roger Chung

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain-disease therapy, a drug delivery system that can sustainably control drug-release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light-traceable and intracellular microenvironment-responsive drug delivery system was developed based on the combination of glutathione-responsive autoflurescent nanogel, dendrimer-like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage-release of sulfydryl-containing drugs into neurons, with light-traceable monitoring for future brain-disease therapy.

Original language	English
Article number	1603966
Pages (from-to)	1-10
Number of pages	10
Journal	Small
Volume	13
Issue number	20
DOIs	https://doi.org/10.1002/smll.201603966
Publication status	Published - 24 May 2017

Keywords

Multistage controlled release
Neurons
Responsive drug delivery
Sulfydryl-containing drugs
Traceable drug delivery

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10.1002/smll.201603966

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AU - Shi, Bingyang

AU - Du, Xin

AU - Chen, Jian

AU - Fu, Libing

AU - Morsch, Marco

AU - Lee, Albert

AU - Liu, Yong

AU - Cole, Nicholas

AU - Chung, Roger

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Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons

Abstract

Keywords

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