Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

Gareth Adlam; Ian S. Blagbrough; Steven Taylor; Harriet C. Latham; Ian S. Haworth; Alison Rodger

doi:10.1016/S0960-894X(01)80405-4

Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

Gareth Adlam^*, Ian S. Blagbrough, Steven Taylor, Harriet C. Latham, Ian S. Haworth, Alison Rodger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N¹-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N¹-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.

Original language	English
Pages (from-to)	2435-2440
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(01)80405-4
Publication status	Published - 1994
Externally published	Yes

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10.1016/S0960-894X(01)80405-4

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Adlam, G., Blagbrough, I. S., Taylor, S., Latham, H. C., Haworth, I. S., & Rodger, A. (1994). Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine. Bioorganic and Medicinal Chemistry Letters, 4(20), 2435-2440. https://doi.org/10.1016/S0960-894X(01)80405-4

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title = "Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine",

abstract = "DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.",

author = "Gareth Adlam and Blagbrough, {Ian S.} and Steven Taylor and Latham, {Harriet C.} and Haworth, {Ian S.} and Alison Rodger",

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doi = "10.1016/S0960-894X(01)80405-4",

language = "English",

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Adlam, G, Blagbrough, IS, Taylor, S, Latham, HC, Haworth, IS & Rodger, A 1994, 'Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine', Bioorganic and Medicinal Chemistry Letters, vol. 4, no. 20, pp. 2435-2440. https://doi.org/10.1016/S0960-894X(01)80405-4

Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine. / Adlam, Gareth; Blagbrough, Ian S.; Taylor, Steven et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 20, 1994, p. 2435-2440.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

AU - Adlam, Gareth

AU - Blagbrough, Ian S.

AU - Taylor, Steven

AU - Latham, Harriet C.

AU - Haworth, Ian S.

AU - Rodger, Alison

PY - 1994

Y1 - 1994

N2 - DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.

AB - DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.

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DO - 10.1016/S0960-894X(01)80405-4

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AN - SCOPUS:0028150637

SN - 0960-894X

VL - 4

SP - 2435

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 20

ER -

Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

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