Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

Gareth Adlam*, Ian S. Blagbrough, Steven Taylor, Harriet C. Latham, Ian S. Haworth, Alison Rodger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.

Original languageEnglish
Pages (from-to)2435-2440
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number20
DOIs
Publication statusPublished - 1994
Externally publishedYes

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