Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resistance in Helicoverpa armigera

Thomas K. Walsh, Nicole Joussen, Kai Tian, Angela McGaughran, Craig J. Anderson, Xinghui Qiu, Seung Joon Ahn, Lisa Bird, Nena Pavlidi, John Vontas, Jaeeun Ryu, Akhtar Rasool, Isabella Barony Macedo, Wee Tek Tay, Yongjun Zhang, Mary E. A. Whitehouse, Pierre Jean Silvie, Sharon Downes, Lori Nemec, David G. Heckel

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)
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Abstract

The cotton bollworm, Helicoverpa armigera (Hübner) is one of the most serious insect pest species to evolve resistance against many insecticides from different chemical classes. This species has evolved resistance to the pyrethroid insecticides across its native range and is becoming a truly global pest after establishing in South America and having been recently recorded in North America. A chimeric cytochrome P450 gene, CYP337B3, has been identified as a resistance mechanism for resistance to fenvalerate and cypermethrin. Here we show that this resistance mechanism is common around the world with at least eight different alleles. It is present in South America and has probably introgressed into its closely related native sibling species, Helicoverpa zea. The different alleles of CYP337B3 are likely to have arisen independently in different geographic locations from selection on existing diversity. The alleles found in Brazil are those most commonly found in Asia, suggesting a potential origin for the incursion of H. armigera into the Americas.

Original languageEnglish
Article numbere0197760
Pages (from-to)1-19
Number of pages19
JournalPLoS ONE
Volume13
Issue number11
Early online date10 Aug 2018
DOIs
Publication statusPublished - 1 Nov 2018
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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