Multiplexing slanted spiral microchannels for ultra-fast blood plasma separation

M. Rafeie*, J. Zhang, M. Asadnia, W. Li, M. E. Warkiani

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

The ability to efficiently fractionate blood into its individual components is crucial for therapeutic and diagnostic purposes. Here, we developed an inertial microfluidic system for cell focusing and blood plasma separation. First, polystyrene beads and blood cells were used to investigate the inertial focusing performance of a single slanted spiral microchannel as a function of particle size, flow rate, and the haematocrit (HCT) concentration. Next, we built a high-throughput system consisted of 16 interconnected spiral channels which can process diluted samples at 24 mL/min. The proposed multiplexed system surmounts shortcomings of previously-reported microfluidic systems concerning throughput, yield and operation efficiency.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages906-907
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period9/10/1613/10/16

Keywords

  • Blood
  • High-throughput
  • Multiplexing
  • Plasma separation

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