Multiscale study on hemodynamics in patient-specific thoracic aortic coarctation

Xi Zhao, Youjun Liu, Jinli Ding, Mingzi Zhang, Wenyu Fu, Fan Bai, Xiaochen Ren, Aike Qiao*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

In this challenge, we intended to mimic the patient's cardiovascular system by using 0D-3D connected multiscale model. The purpose of the multiscale analysis is to find out the appropriate boundary conditions of the innominate artery (IA), left common carotid artery (LCA) and left subclavian artery (LSA) in the local 3D computational fluid dynamics simulation. Firstly, a lumped parameter model(LPM) of the patient's circulatory system was established which could mimic both the rest and stress conditions by adjusting parameters like elastance function of the heart and the peripheral resistance, since that administering is oprenaline leads to the patient's heart beat rate and peripheral resistance changes. Secondly, the values of parameters in the LPM were slightly revised to match the following conditions: 1. provided pressure and flow rate curves, 2. provided blood distribution ratio of the AcsAo, IA, LCA and LSA. Finally, we got the outlet conditions of the IA, LCA and LSA, and then connecting the 0D model and the 3D model at each time step. As the results, we got the streamlines, pressure drop through the coarctation, pressure gradient, and some other parameters by coupled multiscale simuation.

Original languageEnglish
Title of host publicationStatistical Atlases and Computational Models of the Heart
Subtitle of host publicationImaging and Modelling Challenges - 4th International Workshop, STACOM 2013, Held in Conjunction with MICCAI 2013, Revised Selected Papers
EditorsOscar Camara, Tommaso Mansi, Mihaela Pop, Kawal Rhode, Maxime Sermesant, Alistair Young
Place of PublicationBerlin
PublisherSpringer, Springer Nature
Pages57-64
Number of pages8
ISBN (Print)9783642542671
DOIs
Publication statusPublished - 2014
Externally publishedYes
Event4th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2013, Held in Conjunction with MICCAI 2013 - Nagoya, Japan
Duration: 26 Sep 201326 Sep 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8330 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other4th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2013, Held in Conjunction with MICCAI 2013
CountryJapan
CityNagoya
Period26/09/1326/09/13

Keywords

  • Computational fluid dynamics
  • Hemodynamics
  • Multiscale simulation
  • Pressure gradient
  • Thoracic aortic coarctation

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