Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Longkuan Xiang, John A. Kalaitzis, George Nilsen, Li Chen, Bradley S. Moore*

*Corresponding author for this work

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

Original languageEnglish
Pages (from-to)957-960
Number of pages4
JournalOrganic Letters
Volume4
Issue number6
DOIs
Publication statusPublished - 2002
Externally publishedYes

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