Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Longkuan Xiang; John A. Kalaitzis; George Nilsen; Li Chen; Bradley S. Moore

doi:10.1021/ol0255155

Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Longkuan Xiang, John A. Kalaitzis, George Nilsen, Li Chen, Bradley S. Moore^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

Original language	English
Pages (from-to)	957-960
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	6
DOIs	https://doi.org/10.1021/ol0255155
Publication status	Published - 2002
Externally published	Yes

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abstract = "A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.",

author = "Longkuan Xiang and Kalaitzis, {John A.} and George Nilsen and Li Chen and Moore, {Bradley S.}",

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AU - Xiang, Longkuan

AU - Kalaitzis, John A.

AU - Nilsen, George

AU - Chen, Li

AU - Moore, Bradley S.

PY - 2002

Y1 - 2002

N2 - A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

AB - A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

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U2 - 10.1021/ol0255155

DO - 10.1021/ol0255155

M3 - Article

C2 - 11893195

AN - SCOPUS:0037149649

SN - 1523-7060

VL - 4

SP - 957

EP - 960

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Abstract

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