Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Longkuan Xiang; John A. Kalaitzis; George Nilsen; Li Chen; Bradley S. Moore

doi:10.1021/ol0255155

Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Longkuan Xiang, John A. Kalaitzis, George Nilsen, Li Chen, Bradley S. Moore^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

Original language	English
Pages (from-to)	957-960
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	6
DOIs	https://doi.org/10.1021/ol0255155
Publication status	Published - 2002
Externally published	Yes

Access to Document

10.1021/ol0255155

Cite this

@article{e7706b9920da490a80f0bc0994884446,

title = "Mutational analysis of the enterocin favorskii biosynthetic rearrangement",

abstract = "A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.",

author = "Longkuan Xiang and Kalaitzis, {John A.} and George Nilsen and Li Chen and Moore, {Bradley S.}",

year = "2002",

doi = "10.1021/ol0255155",

language = "English",

volume = "4",

pages = "957--960",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Mutational analysis of the enterocin favorskii biosynthetic rearrangement

AU - Xiang, Longkuan

AU - Kalaitzis, John A.

AU - Nilsen, George

AU - Chen, Li

AU - Moore, Bradley S.

PY - 2002

Y1 - 2002

N2 - A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

AB - A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

UR - http://www.scopus.com/inward/record.url?scp=0037149649&partnerID=8YFLogxK

U2 - 10.1021/ol0255155

DO - 10.1021/ol0255155

M3 - Article

C2 - 11893195

AN - SCOPUS:0037149649

SN - 1523-7060

VL - 4

SP - 957

EP - 960

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Mutational analysis of the enterocin favorskii biosynthetic rearrangement

Abstract

Access to Document

Other files and links

Fingerprint

Cite this