Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

Caroline Vance, Boris Rogelj, Tibor Hortobágyi, Kurt J. De Vos, Agnes Lumi Nishimura, Jemeen Sreedharan, Xun Hu, Bradley Smith, Deborah Ruddy, Paul Wright, Jeban Ganesalingam, Kelly L. Williams, Vineeta Tripathi, Safa Al-Saraj, Ammar Al-Chalabi, P. Nigel Leigh, Ian P. Blair, Garth Nicholson, Jackie De Belleroche, Jean Marc Gallo & 2 others Christopher C. Miller, Christopher E. Shaw

Research output: Contribution to journalArticle

1646 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in 10% of cases. We have identified a missense mutation in the gene encoding fused in sarcoma (FUS) in a British kindred, linked to ALS6. In a survey of 197 familial ALS index cases, we identified two further missense mutations in eight families. Postmortem analysis of three cases with FUS mutations showed FUS-immunoreactive cytoplasmic inclusions and predominantly lower motor neuron degeneration. Cellular expression studies revealed aberrant localization of mutant FUS protein. FUS is involved in the regulation of transcription and RNA splicing and transport, and it has functional homology to another ALS gene, TARDBP, which suggests that a common mechanism may underlie motor neuron degeneration.

Original languageEnglish
Pages (from-to)1208-1211
Number of pages4
JournalScience
Volume323
Issue number5918
DOIs
Publication statusPublished - 27 Feb 2009
Externally publishedYes

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