TY - JOUR
T1 - Mycobacterial nucleoid associated proteins
T2 - An added dimension in gene regulation
AU - Kriel, Nastassja L.
AU - Gallant, James
AU - van Wyk, Niël
AU - van Helden, Paul
AU - Sampson, Samantha L.
AU - Warren, Robin M.
AU - Williams, Monique J.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Nucleoid associated proteins (NAPs) are known organisers of chromosomal structure and regulators of transcriptional expression. The number of proposed NAPs in mycobacteria are significantly lower than the number identified in other organisms. An interesting feature of mycobacterial NAPs is their low sequence similarity with those in other species, a property that has hindered their identification. In this review, we discuss the current evidence for the proposed classification of six mycobacterial proteins, Lsr2, EspR, mIHF, HupB, MDP2 and NapM, as NAPs in mycobacterial species with an emphasis on their roles in modulating chromosome structure and transcriptional regulation. In addition, we highlight the technical difficulties associated with investigating and providing evidence for the classification of proteins as NAPs in mycobacteria. We also address the role of mycobacterial NAPs as mediators of stress responses and highlight the recent developments aimed at targeting NAP-DNA interactions for the development of novel anti-TB drugs.
AB - Nucleoid associated proteins (NAPs) are known organisers of chromosomal structure and regulators of transcriptional expression. The number of proposed NAPs in mycobacteria are significantly lower than the number identified in other organisms. An interesting feature of mycobacterial NAPs is their low sequence similarity with those in other species, a property that has hindered their identification. In this review, we discuss the current evidence for the proposed classification of six mycobacterial proteins, Lsr2, EspR, mIHF, HupB, MDP2 and NapM, as NAPs in mycobacterial species with an emphasis on their roles in modulating chromosome structure and transcriptional regulation. In addition, we highlight the technical difficulties associated with investigating and providing evidence for the classification of proteins as NAPs in mycobacteria. We also address the role of mycobacterial NAPs as mediators of stress responses and highlight the recent developments aimed at targeting NAP-DNA interactions for the development of novel anti-TB drugs.
KW - chromosome structure
KW - gene regulation
KW - mycobacterium tuberculosis
KW - nucleoid associated proteins
KW - transcription
UR - http://www.scopus.com/inward/record.url?scp=85038830179&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2017.12.004
DO - 10.1016/j.tube.2017.12.004
M3 - Review article
C2 - 29523320
AN - SCOPUS:85038830179
SN - 1472-9792
VL - 108
SP - 169
EP - 177
JO - Tuberculosis
JF - Tuberculosis
ER -